IUI Treatment in India

IUI - Intrauterine Insemination

What is IUI?

IUI (sometimes referred to as artificial insemination) stands for intrauterine insemination. It is a fertility treatment that places sperm directly into the uterus.

Who needs IUI?

The IUI procedure can be used to overcome a variety of mild fertility problems, many of them on the male side.

Male infertility indications for IUI are:

  • Low sperm count, in which there are not enough sperm for a decent chance of natural fertilization. The sperm have a lower chance of fertilizing the egg, simply because there aren't as many sperm.
  • Low sperm motility, in which sperm have suboptimal ability to swim up to reach and fertilize the egg.
  • Cervical factor infertility, in which cervical mucus negatively impacts sperm motility.
  • Sexual dysfunction.

IUI is also used when patients use donor sperm, a process called donor insemination. Delhi IVF Clinic works with reputable sperm banks where patients can select and procure semen samples for IUI. Donor insemination becomes necessary when the male does not produce sperm of a sufficient quantity and quality, and semen extraction procedures like Testicular Sperm Extraction (TESE) fail. Donor insemination is also routinely used for single women who want to conceive on their own.

In cases of so-called "unexplained" infertility, some physicians employ IUI. However, since Delhi IVF Clinic does not believe that "unexplained infertility" really exists – we believe that in "unexplained infertility" cases, something important has been overlooked during the diagnostic process – we focus on identifying the root cause(s) and devising a treatment plan that specifically target the root cause(s).

How does the IUI procedure work?

Ovulation induction before intrauterine (artificial) insemination

IUI is usually combined with ovulation induction, a process in which a woman's ovaries are mildly stimulated to produce more than one mature egg. Having more than one mature egg means that the sperm have a better chance of "meeting" an egg and fertilizing it, improving the probability of success.

During ovulation induction, in the weeks leading up to IUI the female patient takes medication to make her ovulate. This can be clomiphene citrate (Clomid), taken in oral tablet form, or a group of medications called gonadotropins, which are injected. Clomid is the mildest form of ovarian stimulant, though it can have some unpleasant side effects. At Delhi IVF Clinic, all patients undergoing ovulation induction are monitored: the growth of ovarian follicles (fluid-filled sacs that contain eggs) is monitored by vaginal ultrasound, and hormone levels are checked by blood tests.

The intrauterine (artificial) insemination process

When the ovaries have a good number of mature eggs, a hormonal injection (hCG) is used to trigger ovulation (release of the eggs from the ovaries). This injection determines when the patient ovulates. Inseminations are timed accordingly, and the male partner produces the sperm, which are washed and prepared in the lab. At Delhi IVF Clinic, we inseminate twice every month in most cases, once just before and again just after ovulation, on consecutive days.

By placing sperm directly into the uterus via IUI, the greatest barrier--the mucus in the cervix--is bypassed, and sperm do not have as far to travel to meet the egg in the fallopian tube. Therefore, more sperm reach the egg, creating a better chance of fertilization.

When is IUI Treatment Recommended?

Intra-Uterine Insemination is recommended for clients in the followings cases:

  • Mild sperm problems.
  • Male sperm antibodies.
  • Unexplained infertility.
  • Cervical problems.
  • Psycho-sexual difficulties.

What is the success rate for IUI treatment?

The average success rate for Intra-Uterine Insemination (IUI) using partner sperm is 15-20% per cycle– with the majority of women conceiving in the first two to three cycles.

The success rate using Donor Sperm is 20-25% per treatment cycle. Most clients may complete 2-3 cycles of Donor IUI treatment with over 50% of these clients achieving a pregnancy.

The female age is the most significant factor as success rates decline from age 40. If not successful after 3 or 4 cycles, the consultant will discuss progressing to donor IVF.

What are the risks of IUI?

The main risk of IUI is the risk of multiple gestations, especially of high-order multiples (triplets or more). This is an inherent risk that is extremely difficult to avoid because physicians have limited control over the number of eggs released at the time of ovulation, and the number of eggs that are fertilized by the semen from the IUI. Physicians try to strike the right balance between good pregnancy chances and a low risk for multiple gestations, but even in best of hands, high-order multiples will happen.

Indeed, some years ago physicians from Delhi IVF Clinic published a classic paper on the subject in the prestigious New England Journal of Medicine (Gleicher N et al., Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins. N Engl J Med 2000;343:2-7). This study demonstrated that, even with best precautions, in IUI there is simply no way to control the number of eggs that are available for sperm to fertilize, and the number of eggs that actually do get fertilized. Delhi IVF Clinic researchers concluded in the paper that a high level of control over the multiple birth risk is only possible through in vitro fertilization (IVF). As a consequence of this paper, the practice of infertility has changed significantly, with the number of IUI cycles declining and number of IVF cycles increasing worldwide.

Fertility practice has come to try to avoid multiple births, especially high-order multiples, because they carry elevated risks, especially of premature delivery. The goal of good infertility treatment is, of course, not only to achieve pregnancy but to achieve pregnancy responsibly, and with as low a risk as possible to mother and newborn children.


Senior Consultant, Director and Infertility Specialist

Dr. Anoop Gupta performs exceptionally well in providing the international level infertility treatments at his super specialty clinic in Delhi, India which is known to all as Delhi IVF & Fertility Research Centre, since the year 1994. Delhi IVF aims at providing the finest medical, emotional, ethics, moral, and most advanced technical support to the couples who are trying to find the solution for their infertility problem.

We are specialized in each and every regard of infertility and provide the extensive services to our patients in IVF, IUI, ICSI-IVF, Assisted Hatching, Embryo Donation, Male Infertility, Surrogate Motherhood, Semen Banking, Embryo Freezing, Natural Infertility Treatments, Sexual and Psychological Problem and try to give emotional and moral support to the infertile patients.

Delhi IVF is a Fertility Research Centre which offers specialized infertility treatments with the help of latest and advance technique for IVF-ET, IUI, IVF – ICSI, assisted hatching, blastocyst culture, Embryo Donation, Egg donation, and Surrogacy. Delhi IVF has the highest success rates for IVF treatments and has a State-of-the-Art Lab equipped with fully latest tools and equipments for infertility treatment, in-house team of potential experts, located with 24 hours emergency services. Our infertile patients get all of these under the one roof.

Dr. Anoop Gupta is a Member of ESHRE (European Society of Human Reproduction & Embryology), ASRM (American Society of Reproductive Medicine), UNFDPA (United Nations Family Development Programme) and he has also attended a number of National & International conferences related to ART (Assisted Reproductive Technology) & presented many papers.

Delhi IVF was founded by Dr Anoop Gupta, a renowned pioneer in fertility medicine, to bring the most advanced reproductive care to people of all cultural, ethnic and economic backgrounds who have one thing in common: the desire to have a baby..

Delhi IVF is a patient-focused organization that offers every new patient the value of its more than 20 years of experience and the trust it has earned by helping thousands of patients with life’s most important journey. We believe that everyone should have their best chance to achieve this dream, regardless of financial background, sexual orientation and ethnicity. Our infertility treatments are affordable and cost-effective defining the best medical care.


  • Offering state-of-the-art fertility treatments
  • Treating patients with extra-care during the complete treatment process
  • Highly qualified and dedicated staff from medical and non medical disciplines, with advanced equipment and modern technology.
  • Developing innovative programs to provide affordable fertility treatments and care
  • Empowering patients with resources, tools and services offering information, education, treatment management and stress reduction.
  • Our staff has extensive experience in infertility treatment, surrogacy and egg donation services.
  • Continually advancing fertility treatment, service and outcomes

If you have undergone IVF treatment at another clinic, has it made you disappointed that every time a different doctor attended you? You were indirectly forced to share your problem every time to a different nurse? Are you having trouble getting the feedback or explanations you need ? At Delhi IVF, all the treatment ( including the consultation, all the ultrasound scans, egg collection and embryo transfers are done personally by by the same doctor). The buck stops with us, we understand your condition and do not delegate any part of your IVF treatment to different doctors and nurses.